P4-033: ABCA1 ACTIVATION BY CS6253 AS A THERAPEUTIC FOR APOE4 -ASSOCIATED ALZHEIMER'S DISEASE
نویسندگان
چکیده
منابع مشابه
Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins
Apolipoprotein E4 (apoE4), the leading genetic risk factor for Alzheimer's disease (AD), is less lipidated compared to the most common and AD-benign allele, apoE3. We have recently shown that i.p. injections of the ATP-binding cassette A1 (ABCA1) agonist peptide CS-6253 to apoE mice reverse the hypolipidation of apoE4 and the associated brain pathology and behavioral deficits. While in the brai...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2019
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2019.06.3692